"You have to go back when the fire starts, so that it doesn't propagate in the entire forest," she says. The study could also lead to new treatments for other neurodegenerative diseases, Lasmézas says, treatments that prevent the cascade of events that leads to brain damage. "Ultimately, it only matters if we actually create a therapy," he says. The next step will be to develop a drug that can do something similar in people, Halfmann says. The trick was to flood the cell with proteins that, in effect, smothered the flame before it could do any damage. Once the team had identified that molecule, they were able to find a way to prevent it from spreading - at least in the lab. "What starts this little forest fire in the brain is a single molecule of PolyQ." The trial-and-error approach worked, Halfmann says. "You just keep bumping into things and eventually you bump into things enough times to figure out exactly what it looks like." "It's sort of like if you're in a dark room and you're trying to figure out what the shape of the room is," Halfmann says. The team placed different versions of PolyQ in a cell, then look for signs of misfolding and clumping. They used genetic tweaks to create hundreds of versions of a protein segment called PolyQ, which becomes toxic in Huntington's. The team developed a way to conduct experiments inside individual cells. It's called nucleation, the moment when a misfolded protein begins to aggregate and proliferate. To do that, they needed to chronicle an event that is fleeting and usually invisible. In essence, Halfmann's team wanted to find the molecular matchstick responsible for the lethal blaze. "And you're trying to figure out what started it." "As the disease progresses you're effectively watching a sort of a forest fire," Halfmann says. Then these clumps of abnormal protein begin to cause nearby proteins to misfold and clump too. Like other neurodegenerative diseases, Huntington's occurs when proteins in the brain fold into an abnormal shape and begin to stick together. People with Huntington's "begin to lose control of their body movements, they have mental impediments over time, and eventually they die," says Randal Halfmann, an author of the study and a researcher at the Stowers Institute for Medical Research in Kansas City, Mo. It "opens the path" to finding the initial event that leads to diseases like Alzheimer's and Parkinson's, says Corinne Lasmézas, who studies neurodegenerative diseases at the Wertheim UF Scripps Institute in Jupiter, Florida. But the study has implications for other degenerative brain diseases, including Alzheimer's. The finding involves Huntington's disease, a rare, inherited brain disorder that cut short the life of songwriter Woody Guthrie. They've also shown how it can be extinguished. Now scientists say they've figured out how the fire starts in at least one of these diseases. Bands Undercover, a project in which musicians interpret one another’s songs, transpires at Knuckleheads at 4 p.m.Diseases like Alzheimer's, Parkinson's, and Huntington's are caused by toxic clumps of proteins that spread through the brain like a forest fire. Neo-soul artist Jass (who also submitted one of KCUR’s favorite Tiny Desk Contest entries this year) headlines a strong bill at Lemonade Park at 7 p.m. A two-hour performance by the Dan Riggs Big Band begins at 6:30 p.m. His set begins at 1 p.m.īrant Jester, Bram Wijnands and several other jazz pianists will participate in a “Roomful of Pianos” recital (4:30-6:30 p.m.) at Upcycle Piano Craft. Alan Voss, a jazz guitarist who released a fine debut album in March, is among the artists performing at Mill Creek Park. Many of the performances sponsored by Make Music Day KC take place in unconventional settings. Kansas City is among the hundreds of cities hosting free performances on Wednesday, June 21. Make Music Day has become a global phenomenon since originating in France three decades ago. Jass Couch's Tiny Desk submission video, shot in a church with golden light streaming through the windows, radiates warmth even before she picks up the mic.
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In 1762 the Campo Marzio dell'antica Roma collection of engravings was printed. In 1761 he became a member of the Accademia di San Luca and opened a printing facility of his own. In the meantime Piranesi devoted himself to the measurement of many of the ancient edifices: this led to the publication of Le Antichità Romane de' tempo della prima Repubblica e dei primi imperatori ("Roman Antiquities of the Time of the First Republic and the First Emperors"). In 1748–1774 he created a long series of vedute of the city which established his fame. He then returned to Rome, where he opened a workshop in Via del Corso. It was Tiepolo who expanded the restrictive conventions of reproductive, topographical and antiquarian engravings. According to Legrand, Vasi told Piranesi that "you are too much of a painter, my friend, to be an engraver."Īfter his studies with Vasi, he collaborated with pupils of the French Academy in Rome to produce a series of vedute (views) of the city his first work was Prima parte di Architettura e Prospettive (1743), followed in 1745 by Varie Vedute di Roma Antica e Moderna.įrom 1743 to 1747 he sojourned mainly in Venice where, according to some sources, he often visited Giovanni Battista Tiepolo, a leading artist in Venice. Giuseppe Vasi found Piranesi's talent was beyond engraving. He resided in the Palazzo Venezia and studied under Giuseppe Vasi, who introduced him to the art of etching and engraving of the city and its monuments. His brother Andrea introduced him to Latin and the ancient civilization, and later he was apprenticed under his uncle, Matteo Lucchesi, who was a leading architect in Magistrato delle Acque, the state organization responsible for engineering and restoring historical buildings.įrom 1740 he had an opportunity to work in Rome as a draughtsman for Marco Foscarini, the Venetian ambassador of the new Pope Benedict XIV. Piranesi was born in Mogliano Veneto, near Treviso, then part of the Republic of Venice. Giovanni Battista (also Giambattista) Piranesi (Italian pronunciation: 4 October 1720 – 9 November 1778) was an Italian artist famous for his etchings of Rome and of fictitious and atmospheric "prisons" (Le Carceri d'Invenzione). He was married to the Queen for 74 years so fair play to him, no mean achievement. I was surprised that Wheeler’s got a mention on the BBC TV news tonight, with photos of a couple of bottle blondes I didn’t recognise, starlet types. They told me that Philip had been a very naughty boy upstairs at Wheeler’s at that time (1963). We went there for the company Christmas lunch one year at a time when Jack and David were looking at making a film about Rachman, the pantomime tabloid villain of the Profumo Affair. When I started my career in Marshall Street, Soho at Solus Enterprises with Jack Hazan, Roger Deakins, Dick Pope and David Mingay, Wheeler’s restaurant still existed in the Cambridge Circus corner of Soho, on Old Compton Street from memory. The bluntness and inappropriateness is the kind of thing, of course, that people loved about him. “Do they pay you properly?” (The CEO is beside me, two feet away.) He gradually made his way across the room and eventually reached us. I’ve no idea why, I just knew it.Īnd that’s what happened. Philip entered right at the other corner of the room but I knew from the moment he entered he was going to come up to me. I was standing beside the CEO of the charity, Sir Roger Singleton. It was a huge room, conference centre scale. I was there with Barnardo’s for whom I was making films at the time. It was in the conference centre named after his wife (The Queen Elisabeth Centre) near Westminster Abbey, where they got married in November 1947. I crossed paths with Prince Philip only once. 1992: HRH The Duke of Edinburgh photographed in the Chinese room, Buckingham Palace After being given away prior to the events of Toy Story 3, Bo returns as a main character in Toy Story 4.īo Peep was created by John Lasseter, Andrew Stanton, Joe Ranft, and Pete Docter for the original 1995 feature film, being based and inspired on the nursery rhyme " Little Bo-Peep". She appears in the first two films as a supporting character, portrayed as a love interest to the protagonist, Sheriff Woody. The character is primarily voiced by Annie Potts. As it is, it is very, very good, the kind of film that's only good for children, even (especially?) the inner ones.Bo Peep is a fictional character appearing in the Disney- Pixar Toy Story franchise. So too are the vending machine aliens, who gape in rapt wonder at the judgment of "the claw." If it reached for pathos a little less often, "Toy Story" would be an undeniable classic. The story itself gets kind of rote with repeat viewings, though the transition to Sid's bedroom and its sad mutilated toys is a genius moment. I like Randy Newman's music, just not here, and while the animation textures are surprisingly lifelike, there are places, especially with Scud the dog but also with the baby's drool, where it falls short. The fact it is instead invested with real heart, and can be watched and enjoyed today just as easily as when it debuted nearly 10 years ago, is a tribute to the people behind it. But given how novel all of this was in 1995, "Toy Story" could have been a lot less thought-through than it was, and still made gobs of money. "A Bug's Life" seems a more worthy apex that story was funnier, worked better on its own merits, and used the animation to better effect. He more than holds his own, and you kind of see where he took off with that note-perfect William Shatner parody he perfected on screen in the underrated "Galaxy Quest." While this movie's use of computer animation makes it a milestone, it neither represents the most innovative use of the technology or the cleverest Pixar-ated treatment of a story. It's the role of the story that gives him the best lines ("I don't believe that man has ever been to medical school"), but Allen delivers them with real panache. Tim Allen gives the movie's best performance, as a newfangled toy that takes Woody's place in Andy's heart but can't bring himself to accept that he's just a plastic plaything. Lee Ermey are standouts in the supporting cast. Don Rickles has the screen role of his career (not that "Kelly's Heroes" was Oscar material) as a prickly Mr. Tom Hanks was the biggest star of the moment when "Toy Story" came out, and he works with that likeability by creating a stable center as Woody the cowboy doll. The voicings of the various toys add to the enjoyability. If Andy was a real boy of his time, there would be a computer and a TV/Nintendo, and not much else. That may be the reason the 1990s bedroom of young Andy is populated by playthings of the 1960s, 1970s, and 1980s. "Toy Story" is the kind of children's movie adults can enjoy just as much, because it very cleverly mines deep deposits of nostalgia from the memory banks. Just in case you were also wondering what happened to all the toys that went missing when you were a kid, the answer is clear: They escaped. and became a senior editor for The New Republic in Washington, D.C. Ioffe spent three years in Moscow, from 2009 to 2012, working as a correspondent for The New Yorker and Foreign Policy. Over the next decade, she contributed articles to The New Yorker, The New York Times, The New York Times Magazine, The Washington Post, Foreign Policy, Bloomberg BusinessWeek, Forbes, GQ, The New Republic, Politico, Buzzfeed, Huffington Post Highline, and The Atlantic. She also worked for the Columbia Journalism School's Knight Case Studies Initiative, writing case studies on complex journalistic issues arising in newsrooms, both in America and abroad. Ioffe began her career as a fact-checker for The New Yorker in 2005. According to Ioffe, the barrier was “necessary for Israel to protect its citizens” against an outburst of attacks by Palestinian suicide bombers, which was rapidly growing from 5 attacks in 2000 to 40 and 47 in 20 respectively. In a college newspaper column published in 2003, she said she supported Israel's “methods of defense against terrorism”, including the construction of the Israeli West Bank barrier. While at Princeton, Ioffe was vice-president of the Princeton Israel Public Affairs Committee. She also received a cash grant of $6,000. Her senior thesis project “A study of the Soviet connection to the Spanish speaking world” was awarded with Stone Davis Prize. She later attended Princeton University where she majored in history with a focus on Soviet history and Russian literature and graduated magna cum laude in 2005. Ioffe attended Beth Tfiloh Dahan Community School where she graduated in 2001. They were refugees "fleeing anti-Semitism" in the Soviet Union. When she was 7, her family emigrated to the United States. She has been working effortlessly in her career and it is no surprise that she earns quite hefty and is living a lavish lifestyle.Ioffe was born in Moscow, to a Russian Jewish family. Julia Ioffe’s net worth is estimated to be at $2 million, according to various online portals. Journalist Julia Ioffe is one of the wealthiest journalists and one of the most well-known we know so far. Julia Ioffe has no previous relationships that we are aware of. Julia Ioffe is not dating anyone as of now. Julia Ioffe is possibly single and has never been married, according to our information. Julia Ioffe’s relationship status as of late 2022 is supposed to be single and not dating anyone | Photo Credit: Instagram As a result, the general public is left to wonder if Julia is single, engaged, married, or divorced. Julia, on the other hand, has not revealed any information or images that may indicate if she has a husband, spouse, or partner. Julia Ioffe is a well-known journalist who is devoted to her family and frequently posts photos of them on her Instagram account. Is Julia Ioffe Married, Who Is Her Husband? Julia Ioffe mostly posts about her work rather than her day-to-day life on her Instagram. Julia Ioffe can be found on instagram under the username She has a total of 3207 posts, 28k followers, and 15 following on her account. To glean more information, he surveyed over 50,000 men and women, and according to the results, the number one application deterrent people have is how sunscreen “feels on the skin” and the number two deterrent revolved around the absence of healthy, clean ingredients. By creating new, ultra-comfy sunscreen formulas (you have options-there’s both a non-aerosol spray and a lotion) that the masses would actually feel motivated to apply, Huffstetler is trying to help. We assess that Kinship - Self Reflect Sunscreen Broad Spectrum SPF 32 can provide reliable sun protection based on the ingredient list. The elephant in the room? We need to actually want to wear the stuff that will do said preventing. : Kinship Self Reflect Probiotic Moisturizing Sunscreeen Zinc Oxide Broad Spectrum SPF 32, Mini Trial Size, 0.26 oz / 7.5g : Beauty & Personal Care Beauty & Personal Care Skin Care Sunscreens & Tanning Products Sunscreens Facial Sunscreens 790 (30.38 / Ounce) FREE delivery January 6 - 10. That said, the threat of complications due to sun exposure hasn’t seemed to penetrate our psyches in quite the same way or with quite as much urgency.Īs Huffstetler pointed out to me, one in five Americans will get skin cancer by age 70 and yet, it is the most preventable form of cancer. This does work well under makeup but for medium and deeper skin tones this may sadly need to be a miss, for reference at the moment, I am a very light Oive Toned shade with mixed heritage.We all know we’re supposed to wear sunscreen to protect ourselves against skin cancer, just like we know we shouldn’t smoke cigarettes in an effort to avoid scary diseases such as lung cancer. Kinship Sunscreens 1 results Sort by Log in/sign up to use Wishlists Kinship Self Reflect Probiotic Moisturising SPF 32 Sunscreen with Zinc Oxide (Various Sizes) EXCLUSIVE 4.0 Stars 1 Reviews 1 from £27. Yet still this did give a very noticeable white cast when I first applied that did fade but still left me looking a little chalky though not the worst I am pale right now, and I couldn't imagine how this would look on me when I haven't been avoiding the sun at all cost for over 6 months. Kinship Self Reflect is a moisturizing probiotic mineral sunscreen for how. Now here's the but, I am very pale for me right now we've only just moved into the spring and the sun hasn't really made an appearance yet in the UK and I've avoided it when it has due to laser hair removal on my face that do over the winter months. Kinship Self Reflect Probiotic Moisturising Sunscreen Zinc Oxide. Kinship Self Reflect Probiotic Moisturising SPF 32 Sunscreen with Zinc Oxide (Various Sizes) EXCLUSIVE. Its champagne-colored tint contains niacinamide to brighten skin while making it the. To recap, there are two camps of sunscreen. Supergoop Glow Screen SPF 40 is makeup primer that also provides sun protection. It feels nourishing without being too heavy (especially for a mineral SPF), it helps soothe and support the skin microbiome and of course, provides broad spectrum protection for even the most sensitive skin and gives the skin this luminosity that I loved. UK Delivery from 32.99 Expert Beauty Advisors HOME OFFERS NEW IN TRENDING Search. What Is Kinfield Sunglow SPF 30 First things first: It’s a mineral sunscreen. About the Product In-depth knowledge about this product Caution Find better scoring products Sunscreens can break down while still in the bottle. Net weight: 6. Slather on daily for broad spectrum protection Coconut & Pineapple Pack: This pack comes with 1 Coconut & Pineapple face and 1 Coconut & Pineapple body sunscreen for head-to-toe protection. For sensitive skin, we also offer a hypoallergenic mineral sunblock for an all-natural barrier. About Sun Sunscreen In our humble opinion, sun care is one of the best forms of self-care. Lower scores are given to better sunscreens and moisturizers. Home Skin Care Suncare Enriched with natural ingredients and antioxidants to help soothe and comfort the skin, all our formulas are water-resistant, non-greasy and long-lasting so you can safely enjoy time spent outdoors. This powerful, reef safe sunscreen provides the ultimate protection with a bouncy, dewy, finisheven during long days in the sun, acting as a daily moisturizer. It terms of the formula, the skincare ingredients, the benefits this formula is a 5* Hands Down! To make it seamless for you to keep your skin protected from the elements, we've pulled together a few dermatologist- and editor-approved sunscreen picks from beloved Black-owned and. Kinship Self Reflect Probiotic Moisturizing Sunscreen Lotion, SPF 32 EWG assumes no responsibility for the accuracy of images presented. Self Reflect is a silky smooth, all-in-one mega-hydrating mineral sunscreen and face moisturizer with SPF, which is water-resistant, for healthy, bouncy, dewy skin. Macy, who wrote the book Dopesick, is a longtime newspaper writer in Roanoke, Va. Kaitlyn Dever and Nicholas Logan portray Betsy Mullam and Walt in the Hulu show. "Appalachians are real people, and they've suffered more than the average Americans," author Beth Macy said. I could achieve a more universal truth a higher truth." I could use as many anecdotes as I wanted. "By fictionalizing, I wouldn't be stuck to the truth of one person's life. "If I made these characters composite characters, I get way more of these anecdotes into these arcs with fewer characters and get more truthful stories into the show," Strong said. Keaton's character doesn't exist in the real world, but many doctors like him helped shape Finnix's story. As they grew addicted, Finnix developed his own dependence on the drug, beginning an odyssey through addiction and recovery that mirrored his patients' journey. Samuel Finnix, a dedicated doctor in a small Virginia mining town who was persuaded by a Purdue Pharma salesman to prescribe Ox圜ontin for his patients. Is Michael Keaton's character based on a real doctor? "I think that a storyline like Dopesick in the somewhat fictionalized narrative can bring a kind of moral throughline that often feels pretty satisfying," added Mann. Brian Mann, NPR's addiction correspondent, said the TV show streamlines the real-life story in ways that can make for more effective TV drama. The Sacklers, however, maintain they did nothing wrong. Hulu's Dopesick also portrays a law enforcement and regulatory system struggling to hold the Sacklers and Purdue Pharma accountable, overwhelmed by their financial, legal and lobbying resources. They're often shown as callous villains with little regard for patients who become addicted or communities devastated by the disease. When it comes to members of the Sackler family who own and control Ox圜ontin manufacturer Purdue Pharma, the series takes a strong position. Anything that didn't feel real wouldn't fly.īut Strong says several characters in Dopesick are fictionalized - their character arcs assembled from the stories of a few different people. "Because we were documenting the crimes of Purdue Pharma, the show needed to feel as real as possible," Macy said. They consulted a doctor who had been addicted to Ox圜ontin who revealed the horrors he suffered. They brought in people from small towns and with opioid abuse disorder. While developing the show, they did extensive research to give the series a feeling of authenticity. Nellie quickly becomes an " it girl" covered by gossip columnist Elinor St. Jack helps Manny secure assistant jobs at Kinoscope (like finding Otto Von Strassberger a new camera to film Jack in an outdoors love scene before nightfall) Manny climbs the studio system's ranks. Manny meets and befriends Jack Conrad, a benevolent but troubled, oft-married film star, and drives the drunken Jack home. The flamboyantly-dancing Nellie is spotted and swiftly recruited to replace Jane in a Kinoscope film during filming, she crudely upstages star Constance Moore. While the elephant walks through, distracting partygoers, Manny helps carry away young actress Jane Thornton, who overdosed on drugs.Īlso attending are Chinese-American lesbian cabaret-singer Lady Fay Zhu and African-American jazz trumpeter Sidney Palmer. Upon meeting, Manny reveals his wish to be part of something bigger. He quickly becomes smitten with Nellie LaRoy, a brash, ambitious self-declared "star" from New Jersey. In 1926 Bel-Air, Los Angeles, Mexican immigrant Manuel "Manny" Torres helps transport an elephant to a debauched bacchanal, rife with clotheslessness, copulation, and cocaine, at Kinoscope Studios executive Don Wallach's mansion. Despite this, the film received five nominations at the 80th Golden Globe Awards (including Best Motion Picture – Musical or Comedy, winning Best Original Score), nine nominations at the 28th Critics' Choice Awards (including Best Picture), three nominations at the 76th British Academy Film Awards, and three nominations at the 95th Academy Awards. It was a box-office bomb, grossing $63 million against a production budget of $78–80 million. The film polarized critics, who generally praised its cinematography, score, editing, production design, lead performances and themes, but were sharply divided on its direction, screenplay, graphic content and runtime. Much of the main cast joined the project between January 2020 and August 2021, and filming took place in Los Angeles from July to October 2021.īabylon premiered at the Samuel Goldwyn Theater in Los Angeles on November 14, 2022, and was released in the United States on December 23, 2022. It was announced that Paramount Pictures had acquired worldwide rights in November 2019. The film chronicles the rise and fall of multiple characters during Hollywood's transition from silent to sound films in the late 1920s.Ĭhazelle began developing the film in July 2019, with Lionsgate Films as the frontrunner to acquire the project. It features an ensemble cast that includes Brad Pitt, Margot Robbie, Diego Calva, Jean Smart, Jovan Adepo, and Li Jun Li. Babylon is a 2022 American epic period black comedy-drama film written and directed by Damien Chazelle. Its sleek stacking block set, however, is better suited for climate-controlled environments. Most Elegant Stacking Blocks Set Sunnylife Lucite Games Jumbling TowerĪs its name suggests, Sunnylife offers colorful items for frolicking in the open air-from bright pool floats to bold beach umbrellas. And no, you don’t have to be good at it to have a ball. If you have an intimate fête on the horizon, and are need an activity that doesn’t solely involve downing glasses of Bombay, check out the best stacking blocks sets around, including the original Jenga. A couple of them are so sleek and eye-catching that it’s worth putting them front and center on your coffee table or mantle. Also, stacking blocks don’t necessarily have to be made of standard wood some are now made of carbon fiber, stone or lucite in a slew of colorways. Note: “Jenga,” the word, is trademarked, which is why different packages feature different titles. For what feels like time immemorial-but really since the 1970s, when Oxford Games created the first Jenga set, deriving the name from the Swahili word kujenga, which means “to build”-dismantling a tower of wooden blocks has been a game-night mainstay. Other terms and conditions apply, contact us for more information. All bookings will require a deposit with the final payment for the event due 30 days prior. Please be advised that we will try to accommodate guests elsewhere, however, we cannot guarantee availability in our other venues.Įxclusive events are subject to availability and weather conditions. Merrymaker Rooftop Bar will close when adverse weather may result in a risk to guests or staff. If you want to book a group, please BOOK HERE.įor groups above 30 people please contact us to see if we can accommodate and for pricing. You can see availability and book for groups of up to 30 people online. Group Bookings:įrom Wednesday to Sunday, we are open! For all bookings above 8 guests will need to confirm their booking with a credit card guarantee. Off-Site Parking Valet Parking Only - Cost 15. We Cannot Accommodate Over-Sized Vehicles, Boats, or Trailers. There is No Over-Night Parking on The Streets of Traverse City. On days we are open we can accommodate larger groups as below. +500 Parking On-Site Parking Available The Hotel Indigo Traverse City Provides Valet Parking Only for 15.00 Per Night Per Spot. Exclusive Events:īook out our rooftop for your special event, maybe celebrate an "oh" birthday or bring your corporate clientele up to our vibrant settingĪn exclusive takeover of Merrymaker is available Sunday - Tuesday with up to 96 guests and a tailored menu and drinks package to suit your tastes. Our chefs will curate a special menu just for you while highlighting the best of local produce. Find out HERE when we will not be open to the publicįunctions at Merrymaker will delight your guests with views from Adelaide's highest rooftop bar. Private Events: Our Rooftop is sometimes booked for private events. We recommend all guests, including those staying at Hotel Indigo Adelaide Markets, make a reservation to avoid disappointment - Book below Please Note: Merrymaker is a small venue. Take a flight of fancy up to the Merrymaker, Adelaide’s tallest rooftop bar. Produce is the star of the show, with our talented chefs allowing delicious regional flavours to speak for themselves - loudly enough to be heard even above the shucking, sipping, lip-smacking and all-out, sky-high good times.Ĭome into our kaleidoscope of colour and be thrilled by a multi-sensory experience that embraces the cultural cooking pot that is our neighbourhood. What will you find on the menu? Fresh seafood, Tasty Tapas and piping Hot Pizzas straight from the oven in our Merrymaker Kitchen. Curated cocktails galore, craft beer and a wine list that pours the Barossa Valley straight into your glass, quench your thirst whilst watching the sunset over the rolling Adelaide Hills. |